Three years later, he was in the vortex of public opinionHan chun rainAn updated study was published。
Recently, the korean spring rain published an article on the pre-printed site biorxivGenetic editorNew article: background free tracking of single rna in living cells using catalticly active case。
A screenshot of the paper on the biorxiv site
The article was written by five authors, followed by feng gao, yue sun, feng jiang, xiaoyue bai, chunyu han, working at the centre for genetic editorial studies of hebei university of technology. Among them, han spring rain is the author of the newsletter。
The summaries and contents of the articles show that rna has important and diverse functions, visualizing the rna separated from living cells and providing basic information about its role. So far, scientists have invented two living rna imaging systems。
The study found that case could be designed as a rna tracking tool. This tool is known as “vn-dcase-vc” and is more effective and usable。
A person close to the korean spring rains said to the chinese science newspaper: “this article is a continuation of the previous korean spring rains work and is aimed at developing genetic editing tools”
Usually, it is first published in advance, without peer review, in order to obtain the right of first delivery。
“the next step in the korean spring rains will be the official journal.” the above-mentioned sources speculate。
Press review
In may 2016, nature-biotech published new genetic editing techniques for the korean spring rain teamNgagoThe story was red-hot by the media with a prototype of the story, “golden to sit on the bench, ten years to hold up”。
During the following six months, individuals and their universities received various kinds of honour and substantial financial support。
At the same time, there are many national genetic-editing scientists who claim that it is difficult to repeat the results of the experiments and question their authenticity。
In august 2017, nature-biotech published an editorial entitled " it's time for the data to speak " and announced the withdrawal of the korean spring rain team's paper from the journal on 2 may 2016。
In september 2018, hebei university of technology issued an announcement that the korean spring rain team was free of subjective forgery. But according to the regulations, the korea spring rains team's honors will be revoked and the korean spring rains team will be terminatedScientific researchProjects and recovery of funding for research。
The han spring rain team responded that the experimental design was flawed and the research process was not rigorous。
According to the above-mentioned sources, the chinese science newspaper: “after this wave, ngago was slowly doing this in china. Their work was difficult to carry out, and even students had no new ideas.”
Recent research at ngago
In february 2019, alexei aravin, professor, department of bioengineering, california institute of technology, united states of america, presented a paper in biorxiv: programmmable dna classage by ago nucleas from mesophalic business unit butyricum and limnothrix rosea。
In may, the paper was published in the academic journal nucleic acids research。
Excerpts from the official paper on nucleic acid research
The study showed that cbago was highly active under various conditions and could be used to programmable kernel fission of single and double-chain dna substrates at moderate temperatures。
In april 2019, kevin v solomon, assistant professor, faculty of agriculture and bioengineering, pudu university, presented a paper at biorxiv: ngago-enhanced homologous communication in e. Coli is mediated by dna endoPlease act。
Checklist of biorxiv paper
The researcher demonstrated the function of ngago in the original nuclear organism and found that it expressed poor expression in non-saltist hosts and that most proteins were not dissolved and inactive even after folding. However, they found that the soluble part of ngago did act as a dna enzyme。
At the same time, studies have found that these incisor activity is essential to enhance complication or gene editing of coliform complication guided by ngago。
In china, in addition to the korean spring rains, some teams are conducting ngago research。
For example, in january of this year, the research team of the agricultural microbiology national focus laboratory of the chinese university of agriculture presented a paper on nucleic acid research。
According to the dissertation summary, the study found that ngago had increased gene penetration or loss in basdella and coliform at 80% - 100% efficiency. Researcher analysis suggests that ngago may have the potential to serve as an editor of the original nuclear host gene, but the mechanism of its operation is unclear。
According to china newsweek last april, six or seven of the country's more powerful scientific institutions in this field were previously interested in ngago。
However, after the korean spring rains thesis was enthusiastically followed and strongly questioned, these researchers gradually withdrew from the research field。
It should be emphasized that the article, which is currently being published by the korean spring rains, is only posted on the pre-print website and has not yet been subjected to rigorous peer review。
