A systematic evaluation and analysis, such as that of dr. Mihara of the shinagawa children's medical centre in japan, showed that the application of lidocaine local and intravenous drugs during the whole body anesthesia was effective in preventing larynx。
Throat spasm is a potentially life-threatening whole-body anesthesia-related complications that are more common among children than adults. There have been many studies on the effects of the use of the lidocaine for the prevention of larynx during general anesthesia. However, due to the low incidence of larynx and insufficient evidence in most clinical trials, its findings remain controversial. In addition, access to medicines in these studies is inconsistent. The aim of the analysis is to assess the effectiveness of lidocaine in preventing larynx in children and to test the best delivery routes。
Researchers searched the medline, cochane clinical control experimental registry, embCase, sciencenet, clinicaltrials. Gov, and the random control test (rct) in the umin clinical trial registry, included in the rct, all reported the effects of lidocaine intravenous or local administration on the incidence of larynx during anaesthesia. The risk ratio (rr) and 95 per cent of the credible interval (ci) were used to indicate the dichotomy. I2 quantification of heterogeneity. Asymmetric tests using funnel maps and begg's to assess bias risk。
The results showed that the analysis included nine studies involving 787 patients. The compound results show that lidocaine is effective in preventing child larynx
Rr 0. 39, 95% ci 0. 24 ~ 0. 66, i2 = 0%; number of patients requiring treatment (nnt) 14 95% ci 9 ~ 38
I don't know. The sub-group analysis showed that both the lidocaine intravenous drug (rr 0. 34, 95% ci 0. 14~0. 82) and the local medicine (rr 0. 42, 95% ci 0. 22~0. 80) were effective in preventing child larynx. Sensitivity analysis showed that the results were not influenced by low-quality studies, i. E., the results were highly credible. The results of asymmetric tests of funnel maps are not significant。
Researchers believe that lidocaine local and intravenous drugs are effective in preventing larynx in children during general anesthesia。
