Aspirin, also known as acetyl acid, is an anti-inflammatory drug of the acetylene type, which is first used for inflammating pain. Scientists later discovered that aspirin had the effect of preventing the slabs from condensing to an anti-fist. With further research on aspirin, many new uses have been identified, such as aspirin, which can reduce myocardial infarction and brain mortality and reduce the risk of colon cancer。
Acetyl acid (aspirin) is the traditional antithermal analgesic, with a combination of anti-blood panels. Acetyl acid (aspirin) has an anti-flammatory properties in the body and can reduce the formation of obstructive embolisms in the surrounding artery. Reactions to the release of the slab and releases of internal adp, 5-ht, etc. Thus, the second slab congregates without the first congregates. Acetyl acid (aspirin) acts as a mechanism for the epoxy acetylization of the blood plate, thus inhibiting the formation of the ring peroxide and reducing the generation of txa2. It can also impregnate membrane protein acetyl and inhibit membrane enzyme, which can also inhibit the functioning of the slab. The inhibition of cyclic oxidation enzymes affects the synthesis of the vascular wall pgi2; it also inhibits the synthesis of the blood plate txa2, i. E. The generation of txa2 and pgi2 at large doses. In case of ischaemic heart disease, coronary artery (ptca) is followed by a coronary artery bridge to prevent short-lived cerebral infarction, stroke, myocardial infarction and reduce the incidence of heart disorders。
The acetyl acid acid, also known as aspirin, inhibits the accumulation of platelets, prevents the formation of clots, which are clinically used to prevent temporary cerebral anatomy, myocardial infarction, arterial embolism and the sclerosis of the aorta. In addition, cholesterol disease can be treated。
Acetyl acid is also called aspirin as an anti-sphyllite. Anti-bembolism: the product inhibits the accumulation of slabs and prevents the formation of a sepsis, which is clinically used to prevent the formation of a sepsis, myocardial infarction, cardiac tremors, artificial heart valves, anaemic fistula or other post-operative haemorrhage. It can also be used to treat unstable heart pain。
Oral biological use was 68 ± 3 per cent, with a peak concentration of 2-3 h blood. The plasma protein amalgamation rate is 50 to 90%. The kidney removal rate was 9. 3 ±1. 1 ml/(min. Kg). T1/220 min; aqueous acid t1/23-5 h, t1/215-30 h at high doses. Plasma effective anti-inflammation concentrations ranged from 150 to 300 μg/ml and toxicity concentrations were > 200 μg/ml. Ninety per cent are excreted by adrenaline, 10 per cent by adrift. The alkalining of urine has resulted in a three to fivefold increase in the excretion of ionizing drugs。
Vitamin c (anti-fascic acid) is a vitamin drug with a certain acidity, there is no problem with corrosive equipment and contamination of the environment, and there is a wide range of reactive properties for chemical reagents, reporting their use in synthetic aspirin: when 6. 3 g hydroacne, 13. 5 ml acetic anhydride, 2 vitamin c tablets, 65°c reaction 20 min, aspirin collection 90. 1 per cent, 75°c response 15 rain, 92. 6 per cent。
Chemical properties
This is a white crystal, m. P. 138 ~140°c, not soluble in water, soluble in alcohol, ether, etc. Acetyl acid is the raw material for the preparation of the 4-hydroxycosin intermediate of the raticide. Sour acid and acetic acid. Micro soluble in water, in ethanol, ether, chloroform, in hydroxide alkali solution or carbonate solution, and decomposition. Common antithermal painkillers. It is used for dethesis, pain, rheumatism, promotion of excretion of urinal acid in the arrhythmia, accumulation of anti-blood panels and cholesterol treatment. Structures, instruments and components used to manufacture outdoors and strong light exposures, such as car body parts, farm machinery components, meters and antithermal analgesics such as electric lamps and headlights, road signs, and for heat, pain and rheumatism, among others, are the earliest applications, the widest and most common anthermal analgesic anti-photamines. There are many pharmacological effects such as dethesis, pain, inflammation, wind temperature and blood-resistant plate accumulation, with rapid and assured effects, easy to diagnose and treat overdoses, and with little sensitivity. It is often used for cold fever, headaches, neurological pains, muscle pains, rheumatism, acute internal wet arthritis, rheumatitis and tooth pains. Acetylic acid, a variety included in the national essential medicines directory, is also an intermediate for other drugs. Check manganese. Organic synthesis. Acetyl acid inhibits the production of prostate cords by inhibiting cycloxygenase (cycloxygenase, prostate h-synthesis), especially with high selectivity for the same type of cox-1. Its resistance is due to the inhibition of cox-1 from coagulation in the plate。
Production methods
Aqueous acid acetylization: add acetic anhydride to the reaction tank (with 0. 7889 times the total quantity of aqueous acid) and two-thirds of aqueous acid, mixing up the temperature and reaction 40-60min at 81-82°c. Temperature to 81-82°c temperature protection 2h. Following the inspection of the aqueous acids, the temperature was reduced to 13°c, crystallization, leaching, water washing and drying, drying up at 65 - 70°c and acetyl acid。
Production methods
It is prepared by mixing aqueous acid with acetic anhydride into three bottles at a reaction temperature of not more than 60°c, or approximately 1h, after which the reaction ends and is poured into ice water, with crystallized, filtered and dried products。
Poisons
Toxicity classification
Highly toxic
Acute toxicity
Oral - rat ld50: 200 mg/kg; oral - hour ld50: 250 mg/kg
Flammable hazard characteristics
Open fire; thermal decomposition of irritating gas
Storage characteristics
Ventilated and dry storage; separate from oxidizers and food additives
Fire extinguisher
Mist water, foam, carbon dioxide, sand。
Occupational standards
Twa 5 mg/m3
