On april 4th, the research team of the pei teng team took a photo of the guangzhou institute of biomedicine and health at the central college
This new stem cell-preparation program has broken through the old methods of reaching out to the winner of the nobel prize and is expected to contribute significantly to the development of regenerative medicine
The return of children is becoming a reality in laboratories. Biologists have developed a set of “magic potions”, followed by “bathing” of cells, which can quickly and well achieve “return to childhood” of various cell types。
After five years of close-off, the research team led by pei ting, a researcher at the guangzhou institute of biomedicine and health of the chinese academy of sciences, revealed the scientific principles of chemical methods for the preparation of stem cells, providing an entirely new scientific perspective and solutions for inducing research and optimizing the preparation of multi-energy stem cells. The results were published online on beijing time, 6 april, in the international stem cell authority magazine cell stem cells。
A unlock password string
Making cells new
The small chemical molecules developed by the pei tien team are designed to induce multi-energy stem cells to “baptize” the cells with two different “waters” in order to “return to childhood” to the state of a multi-energy stem cell。
Multi-energy stem cells are a type of cells that are self-renewal, self-replicating and have the potential to regenerate various tissue organs。
How do these magical “magic pharmacists” induce adult cells to the state of multi-energy stem cells early in embryos' development? The study found that the fate of cells is controlled by the state of dyes within the “information hub” of the cell's core, and that the combined open (1) and closed (0) state of the cell's dye form the state of the cell's fate. This is like a computer binary “cipher string” that can “lock” cells in a given state。
Further research by the scientific team found that around the open chromosome bits of adult cells, the transfer factor family members such as ap-1 and ets were guarded, while in stem cells, the transfer factor family members such as oct, sox and klf were guarded. The “back-to-back” of cells, i. E., the chromosomes guarded by adult cells, are open to closure, while the chromosomes guarded by stem cells are closed to open replacement processes。
According to pei teng, the study is a “cipher string” that uses drugs to fine-tune cell chromosomal dyes, first a set of drugs to “lock” the fate of the cell, then another set of drugs to drive the fate of the cell to the state of a multi-energy stem cell, thus achieving the “return to childhood” of the fate of the cell。
B. New scheme superior to the winner's approach
There is more than one way to “return to old age”, and the new approach of the pei ting team is simpler and more efficient。
Shinya, the winner of the 2012 nobel prize in physiology or medicine, was one of the founders who induced multifunctional stem cells. In 2007, his research team, through experiments with mice, had found ways of inducing human skin cells to characterize embryonic stem cell activity。
This method induces the transformation of stem cells into heart and nerve cells and provides a great help to research to treat multiple cardiovascular inseminations. The method, which exempted ethical constraints on the use of human embryos to extract stem cells, was widely used throughout the world and was referred to by industry as the “massive method in the mountains”。
However, the use of viral vectors for retrogressive recording in mountain stretching research methods is easily carcinogenic and poses a greater risk for subsequent clinical applications. In order to induce body cells to become multi-energy stem cells, scientists in various countries are constantly developing new methods. At a later stage, scientists used chemical micromolecular substitutes for the multi-energy stem cells in the mountains, but there were shortcomings such as the number of steps, the length of time, the inefficiency and the lack of clarity。
One of the authors of the newsletters, liu jing, a researcher at guangzhou biological school, china college of science and technology, said that the new methods of chinese scientists were relatively simple, efficient, required fewer initial cells and were easily standardized and widely applied. In addition, the programme allows for the realization of multiple body-cell types of “return to childhood”, including in vitro hepatocellular cells, which are extremely difficult to cultivate。
C methodology is safe and efficient
Applying the wide market
Dry cell and regenerative medicine, which has flourished in recent years, aims to promote body trauma repair, treatment of disease through stem cell transplantation, division and tissue regeneration, with significant clinical application value and an important indicator of a country's level of life sciences and medical development。
Mr. Pei explained that the new programme discovered, which had not introduced an external gene, was simple to operate, and the conditions for the induction process were uniform and standardized, would provide a safe and efficient stem cell preparation method with a wide market for applications。
At the same time, this approach provides a new direction for the development of drugs to induce a shift in the fate of cells, which will greatly contribute to the development of stem cells and regenerative medicine in the service of health care and hygiene in our country。
Scientists have further developed an understanding of the mechanism for “locking” cell chromosomal ciphers for individual small molecules, and have found that the key small molecule brdu can directly influence the dna structure itself to regulate the chromosomal cipher state, thereby promoting the “return to childhood” of cells. The discovery provided a breakthrough for the development of small molecules that were more efficient and simply used for cell “return to childhood”。
Xie xin, a researcher at the shanghai institute of medicine and deputy director of the national new medicine screening centre of the shanghai institute of central science and technology, stated that our scientists are complementary to each other in the field of compound induction of multi-energy stem cells, an area in which china is among the leading countries in the world。
