“the cloning of thousands, the activation of one article, one article, and the tears of bacteria”. At the shanghai cope forum, which was held this afternoon, the 116th session, “renal transplantation, do you understand?” on the spot, dr. Zhang ming, director of the kidney transplant centre of the genitology hospital of the university of transport, shanghai, explained the phenomenon of immunisation and concluded with a sense of humor, giving laughter to the audience of patients with kidney diseases. Zhang ming stated that the main obstacle to kidney transplantation was immunisation, and that it was hoped that both patients would increase their trust, make reasonable choices about receptors based on their configuration, and follow medical advice when receiving immunosuppression treatment。
Globally, 850 million people suffer from kidney diseases for various reasons. Chronic kidney disease causes at least 2. 4 million deaths annually, the sixth most rapidly growing factor in human growth. Since 2006, the international society for kidney diseases and the international confederation of kidney diseases have designated the second thursday in march of each year as world kidney disease day. This year, 14 march, the fourteenth world kidney disease day, on the theme “renal health for all”。
At present, kidney transplantation is the most effective method of treating chronic kidney failure, but the general public has less knowledge of kidney transplantation. “the elements that determine the long-term kidney function for transplants are derived from the initial function of transplants on the one hand and the rate of loss of kidney function after transplants on the other.” in chang ming's view, the key to the forward prediction of kidney transplant patients is to reduce the rate of loss of kidney function. Factors affecting the rate of loss of kidney function include exclusion, drug toxicity, polyoma virus infections, and relapses, more than 80 per cent of which are related to immunosuppressive treatment。
In general terms, transplant exclusion is an immunological response to “others”. The immune system is like a powerful body for the protection of human beings, and if no immunosuppressive treatment is provided after the kidney transplant, the newly transplanted kidneys are immediately attacked by the human defence department。
What are the biggest barriers to organ transplantation at a micro level? Zhang ming told the audience that it is the highly diverse state of human white cell antigens and the basis for the immune system to distinguish between the body and the aerophysical material. This substance appears to be the key to the opening of an immune system attack and the smart password lock that inhibits the growth of immuno-cell cloning and attacks on “otherostics”. For patients, the safer window for immunosuppressive treatment is the better the white cell antigen formulation。
While waiting for kidneys, patients sometimes question: also waiting for kidney supplies, why do you have to wait months for yourself, while some just have to wait weeks? Zhang ming points to the " common and recognized white cell antigen equivalent genome tables in china " , stating that since different white cell antigen sites have the same probability, some are more common, while low probability is likely to occur only three out of 300,000 people, with a lower probability of different nationalities and races. To this end, zhang ming appealed for the patient to be able to give the doctor sufficient confidence to make a reasonable choice of the receptor based on his or her configuration, for the benefit of both. In addition, medication is strictly prescribed by the doctor in order to ensure kidney health。
