I don't know. There's a difference in bed performance, from a young age to a clear loss of hair to total absence of body hair and scalp. The incidence rate is the same for men and women, and is about 0. 1% - 0. 2% [1-2] of the population. The mechanism may interact with t lymphocyte cells and fur bladder antigens (self-antigens), with long-term immunity pardons for the destruction, hla-i, hla-ii, genes involved in congenital and adaptive immunopathic pathways, as well as the activation of oxidation stress, jak radical enzymes and signal transfer circuits, autoimmune diseases (,,,, allergies, etc.), environmental factors (pressure, diet, etc.) [3-4]. The main treatment methods are currently, external irritants, sensitizers, immunosuppressants, etc。
1,308 nm quasi-molecule laser
308 nm quasi-molecular lasers, mainly for therapeutic purposes, white wind, etc., are the most widely studied lasers for balding. The laser can launch a high dose of uvb (ultraviolet b uvb) and external induction of t-cell collapse. Studies have shown that 308 nm quasi-molecular lasers can induce immunogenic behaviour through water soluble media such as il-4, il-10, prostate e2, groupamine, luminous urine acid [5-7]. Gundagan et al.[8] reported for the first time 308 nm quasi-molecular laser treatments, bald, incorporating 2 cases of patients, using its own back-to-back control method, and treating http: / /pfxbxzz. Paperopen. Com 1 to 2 treatments of 2 to 3 months, energy of 2 mj/cm2, reborn after the patient's treatment has been completed, with no recurrence after 5 to 18 months. The study included a small number of patients and could not completely rule out the possibility of ablution, with certain limitations. Zakaria et al.[9] opts for the same patient's skull to be observed with two hairlines, one disemboweling, 308 nm of quasi-molecular laser exposure, another blank contrast, incorporating 8 cases, two treatments per week for 3 months, initial energy of 50 mj/cm2 < med (minimal erythema dose, med), 50 mj/cm2 added every 2 treatments, and hair regeneration only occurs on the side of the exposure, thus excluding the possibility of loss and withdrawal from subsequent visits for 3 months. Byun et al.[7] chose to observe the same hairbrow and half of it was irradiated with 308 nm lasers, the other half with a blank contrast with energy of 200 mj/cm2, 2 treatments per week, 3 months, 60 per cent (3/5) patients > 50 per cent of their hair re-emergence, which avoids the possibility of spontaneous erosion, but does not report on follow-up time and relapse rates. Arakawa et al.[10] reported 11 cases of incurable paralytic patients receiving 308 nm quasi-molecular laser treatment at intervals of 2 weeks each, with total treatments greater than 16 times, initial energy 200 mj/cm2, after each treatment adding 50 mj/cm2, 36. 36% (4/11) patients > 70% hair rebirth, 18. 18% (2/11) patients 10% ~ 70% first birth, 45. 45% (5/11) patients < 10% hair rebirth. The study found that 308 nm quasi-molecular phototherapy had a significant therapeutic effect on other au patients who could be another option for au treatment. 308 nm the adverse effects of quasi-molecular laser treatment are similar to those of silver crumbs, white phoenix, mainly red spots, decrums, itcharts, pigmentation, water and so on [11]。
2 narrow spectrum uv
The narrow spectrum uv b (narrow-band ultraviolet b; nbuvb) phototherapy has proved to be highly effective and resistant to many inflammatory and oncological skin diseases. The nb-uvb has been included in a list of some spots of bald treatment, which refers to treatment in the south, selection of items [12-13], bayramgürler et al. [14] for 25 cases of aa treated by nb-uvb (312 nm), a retrospect analysis of a total of 17 cases, 1 to 3 treatments per week, initial energy of 0. 2 ~ 0. 3 j/cm2, an increase of 20 per cent each, and a maximum of 1. 8 j/cm2, of which 8 cases (32 per cent) of patients with no taboo diseases receive monthly muscle injections. 4 cases (23. 5%) of massive sprawl and 2 cases (11. 8%) of total baldness received good responses. Four out of six patients who responded well also received one dose of intramuscular sugar cortex hormone per month. When comparing the treatment response of patients receiving systematic hormone injections with those receiving only nb-uvb treatment, the difference in patients receiving a good response is statistically significant, so it is considered that nb-uvb is not an effective treatment. The number of patients entering the province is low, and the follow-up cycle, adverse reactions and relapse rates are not reported. One possible explanation for the non-validity of nb-uvb is that the pathological change of aa may be lymphocytes immersed around the fur bladder, while the wave length of nb-uvb cannot reach [14] because of the depth of the fur。
3 long wave ultraviolet
The long wave uva is the most deep phototherapy method through the skin [15]. It's used to treat scalding moss, special hairs, mucous glucosis, gradual depravity. The possible mechanism for uva to activate the specific path of death of t-cells, b-cells, and premature hyperfertilizers, led to a decline in itn-gamma levels, thus reducing the immune privilege of lymphocytes to activate and destroy the furbags. It also reduces icam-i expression, reduces lymphocytes into tissue [16]. Herz-ruelas et al. [17] included 22 patients, allowing salt to assess the severity and type of disempowerment, to receive 75 uva treatments within six months and to commence treatment 25 times (3-5 per week) with an energy of 30 j/cm2. If the first 25 sessions do not respond (hair regeneration < 75%), the dose is increased to 60 j/cm2. If the result remains unresponsive, 25 more treatments at 120 j/cm2. The results show that all patients have organizational and aesthetic corrections, and 40. 09% (9/22) salt rate s0,36. 36% (4/11) salt rate s1,22. 73% (5/22) salt rate s4. Skin pathology shows a decrease in inflammation cells and an increase in total hair. After treatment, mild drying of the skin can be slowly decomposing, and the pigmentation usually lasts four to six months. Carcinogenicity is a concern in all phototherapy, especially in long-term treatment. Uva uses high doses in hard spots and ad hoc dermatitis, but there are no prior reports [18] of cancer caused by uva treatment。
4. Photobiology regulation
Low energy lasers (low level laser, lll) are lasers with low power density or low energy radiation, also known as “cold lasers”, “soft lasers”. The first lllt (low level laser transfer lllt) equipment was approved by the food and drug administration in 2007 for use in [19]. In 2016, there was international agreement to replace the word “low level” with “photobiomodification pbm” [20]. Photobiology is the use of low energy density red light or near infrared light to have beneficial effects on cells or tissues. The optic window of the biological tissue is about 650 ~ 1,200 nm. At these wavelengths, tissues are maximized by penetrating, and therefore using red or near-red infrared (600 ~ 950 nm) [21] in photobiology regulation. Possible mechanisms for photobiological regulation: inflammation, pain, repair of damaged tissue; use of low energy density red light or near infrared light for beneficial effects on cell tissues; depressing no from cytochrome oxidation, increasing linear particles and membrane levels; effecting on stem cells through linear oxidation; opposite effects on healthy and damaged cells [22]. Mester et al. [23] experimented with rats for the first time in 1967 and proved unexpectedly that lasers (694 nm) can promote hair regeneration. Waiz et al.[24] included 16 cases of patients, using pulsed infrared diode low energy with wavelength of 904 nm to treat bald and bald patients, 4 times/week for 1 month, with energy of 1. 2 mw. At the end of the trial, 32 of the 34 hair-tampers showed hair weights, 29 hair-tips had end hairs, 3 hair-tips had hair hair, and all 7 had no hair regeneratives, with a cure rate of about 94%. No adverse effects were detected, but no post-treatment relapse was assessed. The pbm treatment for baldness is gaining interest, the treatment is less reactive and efficient, and there are fewer large samples of the treatment currently being studied, with better research prospects。
5-point laser
The typical pathologies of baldness are lymphocytes immersed around the fur bladders, and dotted lasers form microheat columns in the skin and re-establish healing processes, including lymphocytes immersion. The mechanism for treating baldness may pass by reducing lymphocyte immersion around the fur bladder, thereby reducing the resting cyst, and increasing the production of long-term cysts to stop the disease from progress [25]. Yoo et al.[26] reported 1 case of vat laser treatment for bald patients suffering from other treatments, 1 treatment per week, 6 months of treatment, with energy ranging from 10 to 15 mj, 1 month of hair rebirth after treatment of vat lasers, 6 months of total rebirth of hair, no adverse reaction during treatment, and no repetition rate and follow-up cycle. The wang et al.[27] study of non-stripping point lasers (1,550 nm) united minodil treatment of balconies, study of 8 cases, 10 treatments every 2 weeks, 10 to 15 mj, total energy density 300 spots/cm2, of which 3 cases (37. 5 per cent) were fully reborn, 2 cases (25 per cent) were reborn 30 per cent - 50 per cent. Of these, 1 (12. 5 per cent) withdrew after three weeks of treatment, 1 (12. 5 per cent) occurred during treatment, 1 (12. 5 per cent) did not improve after treatment, and one patient relapsed after 1 year of follow-up. Nd: yag (1,064 nm) compares with dioxidated carbon dot lasers (10,600 nm) for the treatment of baldness, which includes 32 cases (21 cases of baldness, 2 cases of baldness, 1 case of baldness, 8 cases of hair loss), 1 treatment per 2-8 weeks for one cycle, 2 ~ 3 cycles, 10 mj/cm2. Each patient chooses 3 hairslides, one blank contrast, one line nd: yag laser therapy, one line co2-point laser treatment, and statistically the difference between treatment and control groups is not statistically significant. Following treatment, which is mainly partial temporary pain and pain, the rest has no apparent adverse effects, and the rate of relapse and follow-up cycles are not reported. Point lasers can stimulate the immune response around the fur bag, and they can be a good cure for penetrating deeper joint external drugs。
This may cause psychological harm to many patients. The mechanism of autoimmunopathology behind the baldness is still unclear and may be affected by genetic, environmental and emotional stress[8]. Overall, 308 nm quasi-molecule lasers have been shown to increase the ability of patients to regenerate their hair after treatment by 60% - 77%, making it an important tool for laser treatment of baldness [18]. Nb-uvb has been widely used for dermatological inflammation, although the treatment is written into some bald guidelines, because of its limited penetration capacity, it may not be good at treating it. The uva has a penetrating and powerful feature, and despite the reported small sample of uva treating baldness, it may be a good option without a 308 nm quasim molecule laser. With the approval of the pbm by the fda for treatment of male hormonal dysentery, the study of the pbm mechanism continues, and the pbm has become a cure for the new potential of baldness, and there are a number of small samples that have been developed to demonstrate the efficacy of the pbm treatment for baldness, allowing for further large samples of rct research. Because bald pathology is mainly immersed in lymphocytes and other inflammatory cells around the fur bladder, the dotted lasers can be treated with a combination of external drugs because they penetrate deeper, and studies have reported that treatment is effective and that a large number of samples of rcts can be studied further. Laser treatment the treatment of balconies has less pain than local injection of sugar cortex hormones, less adverse response to more systematic oral sugar cortex hormones, good treatment prospects for future balconies, but more clinical data validation is needed。
