Original. Dr. Ho yeung. Dr. Respiratory
More than once, a patient asked me the question: why did the local doctor not use the dillids to give me pain? The painkillers are not working well, is it because the dellumin hospitals are too cheap to make money
I don't know why this drug is so deep in the heart that it's almost known to the young and the old. Perhaps 20 or 30 years ago, the type of painkillers was extremely scarce, and the duluminine did alleviate the suffering of a number of pain patients. Medical knowledge was constantly being updated, yet many people still had a past perspective. It is even more difficult to imagine that many basic hospitals or other specialists do not know that dulumin is long overdue for cancer pain, and suggest that their late cancer patients go to the pain clinic for dulumin。
Why don't the dulumines be used for cancer pain
The chemical name of doutine is hydrochloride tether, and who has explicitly proposed that the dichloride beryllium be treated without moderate cancer pain. The reasons for this are as follows:
1. Short stings of hydrochloric acid beryllium, typically 2-4 hours, compared to morphine (4-6 hours)
2. 1/10 per cent of morphine only for the acreage pain of acrylic acid
3. The short duration of the operation, the need for repeated injections, and the unstable concentration of blood medications are not conducive to the stable control of pain
4. The metabolic metabolite of hydrochloric acid beryllium is weak, but neurotoxic, and long-term use can produce tremors, spasms, convulsions and is not constrained by naloxone。
5. Since the dulumines do not have oral formulations, they can only be injected under the skin or muscle, repeated muscle injections may cause local muscle and tissue inflammation and condensation, and even heavy fibrosis of the muscle tissue。
The rapid rise in blood and brain concentrations following dluminium injections is prone to high concentrations that give rise to a sense of “dispersion”, long-term use is prone to addiction, mental dependence occurs, dluminium is likely to become addicted for one to two weeks in a row, and cessation symptoms occur when drugs are discontinued, similar to the behaviour of detoxification。
Delumines reduce myocardial constriction and cause blood pressure to decrease, etc。
It is clear from a series of reasons why dulumin is not used for chronic carcinogenic pain, which is used only for short periods after surgery, but is rarely used in large hospitals, where better drugs are available。
Now that the duluminine is not used for cancer pain, what kind of medicine is it now
In accordance with the who principle of a third-step analgesics, the first step is a non-silent analgesic analgesics, such as scavengers, enthusiasts, venoms, silphants, etc.; a second-step analgesics, such as tramadol, buquetrazine, codeine, etc.; and a third-step analgesics aphrodisiacs, fentanides, morphine embolisms, sulfantoni self-control pain pumps。
Many patients with cancer pains are stimulated by tumour damage rather than simply sterile inflammation. Such pains are described as cancer-related neuropsychiatric rational pain, which is usually more severe, and routine painkillers are not effective, usually using new calcium ion channelants, usually based on opioid analgesics, commonly using prebarin and gaba sprayedtin, or a three-ring antidepressant amitrin。
Doctor of medicine, master's tutor, respiratory section, shanghai city lung hospital, university of toji. Member of the lung function group of the shanghai medical association and member of the chinese medical association. It specializes in the prevention and treatment of lung diseases such as imtct, hysteria and lung cancer。
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