On may 11th, world obesity control day, the web is full of red diet pills. Let's talk about a classic sugar mellitus: two aces. The legend can lose weight. Is that true
The two-academic diaphragm, which is currently the first-line drug for type 2 diabetes, has been used for more than 60 years and is the most prescription sugar medicine worldwide. The treatment of diaphragm is also being expanded to include pre-diabetes, gestational diabetes and polyseptic ovaries. The study also found benefits for various diseases (cancer, obesity, liver, cardiovascular disease, kidney disease and pre-eclampsia)。
A two-decaree diet
There is a constant flow of “good use” for weight loss with two-decabdes. From a metabolic point of view, it is true that amitraz can lead to a reduction in liver glucose altruism and reduction in insulin production, associated with weight loss. At the same time, new evidence suggests that weight reductions associated with diaphragms may also be associated with the regulation of subdural appetite centres, leading to changes in intestinal microorganisms and slowing ageing。
There are also doctors specializing in the good use of “weight loss”. In 2012, a german scholar, seifarth, examined outpatient obese and overweight patients [bmi ≥27kg/m2] for the effectiveness of the two-decatradium as a diet drug, at doses not exceeding 2,500 mg per day. After six months, the average body weight of patients who were on the diaphragm was reduced by 5. 8 ± 7. 0 kg, while those who were not treated increased by an average of 0. 8 ± 3. 5 kg; and the weight loss ratio was not related to age, sex or bmi, which seemed to point to the effectiveness of the diaphragm for obesity。
So, you know, i'm not fat and i'm not diabetic
I don't want to lose weight on my own
Self-adultation is not advisable for three reasons:
First of all, you're not fat. The weighting effect of 5kg is the average result of long-term treatment for obese patients, which is difficult to achieve for the very small bmi population. Bmi is the most commonly used tool for assessing and screening adults and children for overweight and obesity, which is associated with fat content in the body. Bmi is calculated as weight (in kg) divided by height (in m). Normal health bmi values are 18. 5-25. 0. At present, there are three types of individuals suitable for diet treatment: 1 bmi30; 2 bmi 27-29. 9 with body weight-related co-existence diseases (such as diabetes mellitus, heart disease or hypertension);3 a simple, comprehensive lifestyle intervention that does not meet the weight reduction target (with an overall reduction of at least 5 per cent over a period of three to six months) is appropriate for treatment。
Second, the side effects of the diaphragm are not acceptable to all, and enhanced safety monitoring, including regular checks on vitamin b12 and kidney functions, is required during the medication. The most common adverse effects of diarrhea are gastrointestinal discomfort (expressed in nausea, vomiting and diarrhoea), followed by changes in mental state, rapid breathing and low blood pressure. Long-term use may also result in toxic accumulation and reduction of vitamin b12 levels in lactate. Severe lacid acid poisoning can show headaches, limb weakness, lip purple, blood pressure drops, heart rate increases, cognitive impairments and even shock and coma. It is therefore prohibited for patients with lactacid acid (e. G. Kidney function impairment, combined activity or liver disease, alcohol abuse, past history of lactate poisoning, low injection/aerobic deficiency, etc.)。
Finally, two-acre diaphragms are not in the national and international diet. The integrated management guide to type 2 diabetes of the united states institute of endocrinology explicitly lists seven diet drugs currently in use in the united states (pentrimin, orishta, clokacerin, fentemin/topolythrin retardants, natoxone/antoxone, liralupine), which are not included. In china, olith was the only non-prescribed diet medicine that had been approved for listing by the national drug food supervisory authority (sfda)。
"fair loss" in certain special circumstances
1. Adults and adolescents overweight or obese and non-diabetes
The two-acre diaphragm is not only related to weight loss among obese diabetic type 2 patients. More importantly, a web-based analysis conducted in 2019 showed that two-acre diaphragms had a good effect on diets of overweight or obese and diabetes-free adolescents and adults, and that two-acre diaphragms had a significant impact on bmi and had a lesser impact on metabolic indicators. In addition, 1,000 mg/day for three months may be the most appropriate treatment for overweight or obese adolescents; 3,000 mg/day for six months and 1,000 mg/day for 0. 5 months for obese and diabetes-free adults。
2. Obesity on anti-psychotic drugs
While anti-psychiatric drugs are very effective for mental illness, severe impulses and emotional instability, they can lead to frequent weight gain and metabolic syndrome. Several random clinical trials have confirmed the effectiveness of weight gain from antipsychotic drugs, but have not been included in the relevant clinical guidelines. Varuni et al. Carried out an analysis (a total of 743 patients treated with antipsychotic drugs) and found that the average weight reduction of 3. 27 kg after the two-academic treatment was compared to the placebo, which also resulted in a significant reduction in the bmi and insulin resistance index。
3. Pre-diabetes
Non-diabetes patients with increased blood sugar levels are at risk of progress to type 2 diabetes, commonly referred to as “pre-diabetes”. Pre-diabetes usually refer to loss of abdominal sugar, sugar tolerance and metabolic syndrome. The u. S. Guide now considers hba1c to also represent pre-diabetes. The risk of micro- and large-vascular damage to patients with pre-diabetes sugar abnormalities has increased, similar to long-term complications of diabetes。
In my country's " consensus of experts on the clinical application of amitraz " , it is stated that the two-acre diaphragm is the first drug proven to prevent or slow the occurrence of diabetes. The diaphragm is effective in reducing the risk of type 2 diabetes among the pre-diabetes population and has good tolerance and long-term effectiveness. However, the prevention of diabetes in our country is not yet an adaptation. The fda also does not authorize any drug (heavy or sugar) to be used only for pre-diabetes or to prevent the occurrence of type 2 diabetes. The 2017 edition of the guide by the american diabetes society suggests that pre-diabetes patients, especially those with bmi > 25, who are younger than 60 years of age, women with a history of pregnancy diabetes, etc., can be treated to prevent diabetes based on lifestyle interventions。
Summary
Maintaining exercise and balanced diet are at the heart of the weight reduction。
2. Self-adultation is difficult to monitor for safety and some patients are at risk of lactating acid poisoning。
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There is also a need for more clinical experience and evidence on overadaptative medications for special patients (adult or obese and non-diabetes adults and adolescents, obese on anti-psychiatric drugs, pre-diabetes)。
This is all of today's content, and if you think it's a good article, we'll see it next time。
