"doctor, i've got a normal blood sample. Can i stop the medicine?"
"does it come back early? It's too late for that. What do we do
The post-transplant stoppage is not a “headshot decision”, but a clear “threshold” — meeting these standards would make it safer; failure to meet the standards would be forced to stop and the risk of recurrence would soar。
Understand: why can't we stop drugs after the transplant
Blood stem cell transplants (known as “transplants”) are “the cure” for many leukaemias, but the immune system of the transplanted patient is like “a newly rebuilt house” — new immunocells (from suppliers) take time to “adapt to the environment” and the original abnormal cells (residuous leukaemia cells) may “take advantage of the false entry”。
There are two possible risks if there is a premature withdrawal (e. G. Immunosuppressants, hormones):
We have to meet these five hard targets
The doctor adjusts the criteria to the specific circumstances of the patient (age, type of disease, type of transplant), but the following five are “common thresholds” that will be considered for stoppage once the standard is met:
Long-term stability of blood elephants: white cells, plateboards, haemoglobins “standards and no fluctuations”
Following the transplantation, the blood elephants (especially neutral particle cells, platelets) are a “brainwatch”:
Focus: blood elephants cannot be “tweaked and low” — for example, today's plate 50 and fall to 20 tomorrow, indicating that the bone marrow is still in a “floating period” and cannot stop。
Unactive infections or haemorrhaging: body “no fighting”
Infection (e. G. Pneumonia, oral ulcers) and haemorrhage (e. G. Dental haemorrhage, nose haemorrhage) are the most common “roadblockers” within three months of the transplant. If:
Feeder cell “dominant”: nesting rate > 95%
Following the transplant, doctors will use the embedded ratio test to see if the blood cells of the supplier “take over” the bone marrow of the patient:
Minimal residual (mrd) negative: "unsighted enemy" eliminated
Mrd is a “carcinary cell hidden in bone marrow” in very small numbers but with a potential for recurrence. If:
Immunosuppressants “progressive reduction”: new body “adaptation” balance
Patients after transplants are usually required to take immunosuppressants such as his gramos and cyclists. Before we stop, the doctor will:
Focus: immunosuppressants cannot “suddenly” — like “slow release” — and it takes time for the body to adapt to “no drug protection”。
The doctor reminds that these three things are more important than “cut off”! Don't have a three-month stoppage with someone else than “cut off” time, one year — everyone recovers at a different rate and listens to the doctor's “self-contained programme” best; do not “leav yourself” after the stoppage, even if it has met the standard, and keep a regular review (blood routine, coding ratio, mrd) for the first three months to guard against the recurrence of “deep out”; maintain “health habits” balanced diets (over high proteins, fresh vegetables), avoid infection (face masks, hand-washing) and moderate activity (20 minutes per day) to help “hold the line”。
