Units: taiwon city, scientific research department, centre for clinical testing of children's hospital, shanxi province (jhu yi); taiwon city, taiwon golden field clinical laboratory (zhu gyeongyi)
Micro-ecological formulations, also known as micro-eco-regulating agents, are based on micro-ecological principles, using formulations made from normal micro-organisms and their metabolic products and growth promotion substances that are beneficial to the host, to improve the health of the host by adjusting and maintaining a micro-eco-balance through enzyme, antibacterial, adhesive and biological barriers. Micro-ecological formulations are also called probiotics, prebiotitcs and synbiotics, which are guided by micro-ecological theory to adjust ecological disorders (microdysbiosis), maintain micro-ecological balance (microeubiosis), improve the health of host (humans, animals and plants) or improve healthy health (wellbeing) biologically active microbacterial products (microbials) and their metabolites, as well as material products that promote the growth and reproduction of these biota. As early as the 1970s, our microbiologists, professor liu zhongyang and professor chongbai, among others, have begun research on micro-ecological agents, which, after many years of development, is now widely used in various sectors, including health care and food. Micro-ecological agents, unlike other medicines, are superior to antibiotics, overcoming the strain disorders caused by the application of antibiotics, the increase in drug-resistant strains and the toxic side-effects of drugs, increasing their immunity, safeguarding human health and combating diseases。
01 micro-ecological formulation classification
1. Based on the material composition of micro-ecological agents, they can be divided into life-saving, life-saving and congener。
2. Based on the type of micro-organism: can be divided into germella sprout formulations, bacillus formulations, yeast formulations and composite micro-ecological formulations。
3. Based on the uses and mechanisms of micro-ecological agents: micro-ecological food additives and micro-ecological health products; based on the composition of bacteria, they can be divided into mono-bacterium formulations and micro-bacterial formulations。
2. Micro-ecological agent mechanisms
The intestinal tract is one of the largest immunological organs in the organism, and changes in the composition and function of the digestive fungus affect the respiratory tract through the mucous immune system, while the respiratory fungus disorder affects the digestive tract through immuno-regulating. The result of intestinal micro-ecological disorders is an increase in opportunistic bacteria, leading to degradation of intestinal mucous, increased intestinal membranes penetration, disruption of the intestinal barrier function, increased risk of infection and subsequent bacterial infections。
1. Regulates the micro-ecological balance of the intestinal tract: the porphyria vegetacillus can contribute to the growth and inhibition of the growth and reproduction of harmful strains, such as bicobacteria; and the pyroptococcus, which is adhesive and forms a intestinal microbial barrier, produces bacterial inhibition and inhibits the adhesion, planting and invasion of the intestinal tract by alien pathogens。
2. Reduction of viral infections: bacterium butate, which reduces respiratory virus infections following blood stem cell transplants and reduces pulmonary pathological damage and vascular seepages; bacterium lactate, which induces lung type 1 interference (ifn-i), triggers cell protection and antivirus response。
3. Promotion of nutrient absorption: pyrochlor, primary butic acid (approximately 80 per cent), butic acid is the main energy source for the maintenance of normal breathing of intestinal skin cells; bicoccus and bacillus, mainly lactating acid and acetic acid, regulate intestinal ph, which can be converted into butacelic acid to provide for intestinal skin energy. In addition, multiple vitamins, such as folic acid, b vitamins, vitamin k, etc., have been synthesized for the intestinal barrier。
4. Reinforcement of the intestinal barrier: porpoise and duplexella, promotion of the expression of closely connected protein in the intestinal skin, promotion of the growth of intestinal skin cells, maintenance of the integrity of the upper intestinal skin and reduction of infection. Plant bacillus, which has a target and repair of the mitochondrial particles in the intestinal skin cells damaged by the virus to repair the intestinal barrier。
5. Enhancement of human immunisation: puffy cheese acid, induction of tgf-β, promotion of itreg cell proliferation, regulation of immunisation function; bi-baby, inhibition of nf-100 beta activity, inhibition of intestinal mucous lesions caused by il-1b. Bipolar bacteria, inhibiting the generation of aerodynamic inflammation factors, increasing the body's anti-inflammatory cytology, enhancing the virulence and oscillation of natural lethal cells and acting as an immune function。
3 micro-ecological formulations used in the fight against the new crown virus (covid-19)
Corona virus, a positive single-chain rna virus, is a large family of viruses, divided into alpha, beta, gamma and thorium, with beta coronary viruses divided into four separate subgroups a, b, c and d, which are important pathogens for many livestock, pets and human diseases. Seven coronal viruses are known to cause human disease: hcov-229, hcov-oc43, hcov-nl63, hcov-hku1, sars-cov, mers-cov, covid-19. Originally, the coronary virus caused respiratory and intestinal infections only in animals and humans, and clinical performance was low, with infections occurring only in populations with low immunity. Until 2002-2003, the emergence of coronary viruses, known as severe acute respiratory syndrome (sars), and the middle east respiratory syndrome (middle east resspiratory syndrome, mers), attracted global attention。
Covid-19 is a new type of coronary virus, classified as beta coronary virus, found in our sudden case of atypical pneumonia in wuhan at the end of 2019. On 11 february 2020, who officially named 2019-ncov the new coronary virus (covid-19). The international classification of viruss (ictv) formally classifies it as sars-cov-2. Covid-19 is mainly responsible for new coronary pneumonia, with severe cases of respiratory difficulties and/or low oxygen haemorrhagic disorders, which can lead to deaths due to acute respiratory distress syndrome, sepsis, incurable metabolic acid poisoning and condensation disorders and multi-organ failure。
At the international level, there is a large number of covid-19 variants in a number of european and american countries, including alpha, beta, gamma, thorium and omicron variants, especially the omikronian branch, of which bq. 1 and xbb are new variants of omikron and are the dominant strains of the current international spread of new coronal viruses. The main manifestation is increased communication and immunity flight capacity. However, there is no significant difference between its pathogenicity and other strains of omikron, and the incidence of severe diseases and mortality has not increased significantly in countries with epidemics of bq. 1 and xbb. Over the past three months, more than 130 sub-divisions of omikron have entered the country and have been monitored for transmission to bf. 7, bq. 1, xbb, including bq. 1 and xbb, ba. 5. 2, bf. 7, b. 1. 1. 7, b. 1. 351 and p. 1 variants. Currently ba. 5. 2 and bf. 7 are dominated, but their dissemination advantages will gradually increase, with the possibility of creating a cycle with more than 50 sub-divisions. Globally, since the discovery of the omikian strain, more than 750 branches have evolved globally, the first two being xbb2. 75 and bq1. 1 variants, which account for a high proportion of new coronary virus infections in some countries. Xbb1. 5, one of the sub-divisions, has seen a further increase in its dissemination, which has been monitored in at least 40 countries and territories. From 1 december last year to 10 january this year, 19 branches of omik evolution have been monitored from 31 provinces and legionnaires, with b5. 2 and bf7 taking the absolute advantage。
The covid-19 infection has increased protection for the elderly and persons with basic diseases, especially those with low levels of immunity. The micro-ecological balance of the human body is a key safeguard of physical health, and at a time when the micro-ecological balance of the intestinal system is balanced, the intestinal barrier has been constructed in the intestinal microbial population of the human body against invasion by alien bacteria. When the human body is infected with covid-19, which leads to oxygen deficiency in the respiratory tract, bacteria in the intestinal tract also suffer from oxygen deficiency, resulting in micro-ecological disorders in the human body and a vulnerability to bacterial transfer leading to subsequent infections. Many people die not from the disease itself, but from secondary infections. It is therefore essential to maintain a micro-ecological balance in the intestinal tract for those infected with the coronary virus. According to national expert studies, many of the cases of serious diseases of the covid-19 epidemic were characterized by intestinal strains that caused bacterial regenerative infections and caused death. The regulation of intestinal micro-ecology has been instrumental in the prevention of the covid-19 infection. For cases of serious and serious diseases, micro-ecological regulation of the intestinal tract can be used to maintain a micro-ecological balance of the intestinal tract and to prevent secondary bacterial infections. According to the report of the zhongnan shan school, the clinical profile analysis of the patients of covid-19 shows a higher incidence of diarrhoea among the severely ill (5. 8 per cent) than among the non-heavy patients (3. 3 per cent). For patients with covid-19, the fungi can be a clinical application option. Covid-19 patients, especially those with severe illnesses, can be helped to prevent secondary infections, regulate strains and improve immune functions. Micro-ecological agents are used in the fight against new coronary virus infections, and there are numerous reports at home and abroad. In its pilot editions 5, 6 and 7 of the health commission's new coronary virus pneumonia treatment programme, it is stated that intestinal micro-ecological agents can be used to maintain micro-ecological balance in the intestinal tract and to prevent subsequent bacterial infections。
My country, professor li lancheng, first introduced the theory of microecologicals of infection in 2001, emphasizing the need to find ways to prevent and treat infection from multiple stages of its occurrence and development, proposing a combination of “bicide and promotion”, promoting the rational application of antibiotics, focusing on the preservation of the microecological balance of the human body, the protection of the function of organs and the enhancement of its immune capacity. Li lancheng points out that micro-ecological therapy, the “quad-anti-two balance”, is important for treating patients with new acute pneumonia, namely, antivirus, shock, anti-oxyoxin and multi-organ functional failure, and anti-retro-infection; the “second balance” includes maintenance of hydrolyte acid alkali balance and micro-ecological balance. In cooperation with the institute of biomedicine of the university of jordan, prof. Xu jianjiang has found that micro-ecological agents can enhance vaccine “immuno” guanke plant coliform, which affects the whole body's immune response mainly by affecting intestinal mucous membranes, promoting the generation and maintenance of a new coronary vaccine, suggesting that the key to combating the epidemic is the balance of intestinal strains. Today, micro-ecological regulators are included by the national commission for health and health in the new coronary virus infection treatment programme, using intestinal micro-ecological regulators, maintaining micro-ecological balance in the intestinal tract and preventing secondary bacterial infections”。
04 basic conditions for micro-ecological formulations and clinical applications
Micro-ecological formulations: the micro-ecological regulation agent, based on micro-ecological principles, improves the health of the host by adjusting and maintaining a micro-ecological balance through enzyme effects, antibacterial resistance, adhesive implantation and biological barriers, using preparations made by normal micro-organisms and their metabolic products and growth promotion substances that are beneficial to the host. Micro-ecological formulations are divided into probiotics, prebiotitcs and synbiotics according to the properties of their components. Bountiful bacteria are living micro-ecological agents that contribute to the balance of intestinal strains and have a beneficial effect on the host. They can be classified as solid (capacitors, tablets) and liquid (oral fluids, fermentation) by formulation type, and as multi-coercive and monobacterial formulations by number of bacteria contained. The living dollar refers to the indigent food component of the host's health by stimulating the growth and activity of the resident bacteria in the host's colon. The living dollar is divided into low-melt (e. G. Soybeans, soybeans, lactating sugar), biopromoting agents and chinese pharmacists. Consistency is also known as hysteres and is a formulation that combines life-saving bacteria with life-saving organisms. The life-cycle effect is enhanced by the activity of the fungi and the selective increase in the number of bacteria。
2. Basic clinical conditions for the application of micro-ecological formulations: non-toxic, harmless, safe and effective; reaching a certain quantity and concentration in a certain volume; resistant to gastric acids, enterases, pancreas and cholesterol. At certain temperature conditions, the survival of the fungi is ensured and the concentration necessary for treatment or prevention is always achieved, adhesive, sedentary and reproductive in the intestinal tract to counteract the pathogenicity of the fungi。
2. Micro-ecological formulations are commonly used in clinical practice: most of the micro-ecological formulations currently used in clinical practice are prophylactic. Beneficiary bacteria typically refer to micro-ecological formulations that contribute to the balance of intestinal strains and make a beneficial contribution to the host or to the formation of fungi. Common prophylactic bacteria include: bipolar fungi, acidic yogurt, intestinal fungus, paraquat bacterium, lithoplasm, cheese acid fungs, intestinal fungs, hot streptococcus, etc. Micro-ecological formulations should be selected in clinical applications based on the clinical characteristics of the patient and the biological characteristics of each micro-ecological formulation. If a normal intestinal fungus is to be established as soon as possible, it would be useful to use a combination of oral transvestite formulations, such as transvestite strains, bacillus acid and intestinal fungs. In the case of diarrhoea or indigestion, multi-dimensional lactate is preferred because of its ability to adjust the intestinal population, facilitate digestion and provide multiple vitamins and micronutrients. Bacillus sprouts accelerate the formation of a low-oxic intestinal environment, promote beneficial growth and inhibit harmful bacteria, especially for pseudo-film intestine or intestinal fungi infections。
3. Clinical applications of micro-ecological formulations: main roles: protection, immunization, sterilization, balance, nutrition, liver protection, blood sugar reduction, etc. Often used for diseases such as infectious diarrhoea, constipation and vaginal strains, the use of clinical disease treatment is becoming more widespread as research deepens. Micro-ecological agents are good immunoactive agents that stimulate host immunosuppressive cells through bacteria themselves or cell wall components, enabling them to activate and facilitating the ingestion of cells. In addition, it enhances the ability of host b cells to produce antibodies and increases the body's own immunity。
4. Application in the fight against covid-19: when the human body is infected by covid-19, which causes a lack of oxygen in the respiratory tract, causes a lack of oxygen in the human intestinal tract, micro-ecological disorders in the intestinal tract, and is prone to bacterial transfer and subsequent infections. For those infected with the coronary virus, it is essential to maintain a micro-ecological balance in the intestinal tract. In cases of acute and acute diseases, micro-ecological agents in the intestinal tract can be used to maintain a micro-ecological balance in the intestinal tract and to prevent secondary bacterial infections. It helps people with covid-19, especially those with serious illnesses, to prevent secondary infections, to regulate strains and to improve their immune function。
In short, micro-ecological agents play an important role in regulating the micro-ecological balance of the human body, maintaining a balance in the intestinal population, applying it to the prevention and treatment of patients with covid-19, preventing secondary infections and increasing the immunity of the organism。
