A multi-country, random-blind, placebo contrast of three clinical trials showed that the porphyllic acid autumn cactus can reduce the risk of cardiac events by an additional 31 per cent for adults with confirmed aneurystic hardened cardiovascular disease (ascvd) based on standard treatment. “the effectiveness of autumn water fairy, which is affordable, has been demonstrated by research and the risk of side effects is low for low-dose use.”
On 20 june, local time, agepha pharma, a united states pharmaceutical company, announced that, following a priority review, the united states food and drug regulatory authority (fda) had approved lodoco (autumn cacthaline, 0. 5 mg tablets) for use in the treatment of scalable cardiovascular diseases (ascvd). According to the company's press release, this was the first anti-inflammatory drug approved by the fda for use in cardiovascular diseases。
Autumn cuisine can reduce myocardial infarction (mi), stroke, coronary blood transport (coro) for adult patientsNarrator: the results of the research supporting its approved listing show that autumn cactus can reduce the risk of cardiac events by an additional 31 per cent for adults who have been diagnosed with cardiac hardened porridges (ascvd) based on standard treatment。
Autumn cuisine is not a new drug. It is a drug extracted from the autumn cactus plant and is said to have been used to treat inflammation as far back as ancient egypt and ancient greece. Since the 1930s, the autumn phenomenon has been used for the treatment of gout, and the low dose of autumn phenomenon is still the first-line treatment for gout。
According to agepha pharma press release, lodoco (autumn cactus, 0. 5 mg tablets) is an oral treatment for adults once a day and once a time. Autumn cuisine inhibits the assembly of micropipes (a fibrous structure prevalent in a genuine nuclear cell) and has multiple anti-inflammation mechanisms that can be used safely, either alone or in conjunction with standard care lipid reduction drugs and other therapies, to effectively reduce the risk of heart attack and stroke。
“for the first time, the introduction of anti-inflammatory drugs for cardiovascular diseases has been approved by the fda, which represents an important step forward in the treatment of patients. To treat coronary diseases effectively, doctors must actively reduce inflammation and cholesterol. For suitable patients already on histinic drugs, the addition of 0. 5 milligrams of anti-inflammatory aqueous alphate per day has been shown to significantly reduce the risk of further myocardial infarction and stroke.” paul ridker, professor of harvard medical school of medicine, and director of the centre for the prevention of cardiovascular diseases of brigham and women's hospital, united states。
“it is a good thing that the autumn water fairy, which has been approved for the treatment of cardiovascular diseases, is cheap and beautiful.” on 25 june, chen hae-ice, a medical practitioner of the endocrine metabolic section of the tenth people's hospital in shanghai, and a long-term pain treatment, told tsing tsing。
According to chen sea ice, the price of the autumn water fairy alkalis used for clinical purposes in the country is $11/box, assuming 10 boxes per year for only $110. In recent years, after several studies have shown the efficacy of the autumn phenomenon, some of the country's cardiologists have tried to use autumn phenomenon for cardiovascular disease treatment, and it has been found that its addition can stabilize patients whose heart has been filled up。
A number of studies have shown that autumn cactus works against cardiovascular disease
The sclerosis of the artery is defined as a series of serious cardiovascular diseases caused by the sclerosis of the artery, such as coronary disease, acute coronary artery syndrome, exterior artery disease, heart infarction and stroke. According to an article in the chinese pharmacy magazine, the sclerosis of the artery is due to the damage to the artery internal membrane, the cholesterol in the blood that enters the artery internal membrane, is consumed by giant cells, forms foam cells, forms a hardened plaque, leads to hardening of the vascular wall, narrowening of the vascular cavity, etc. If the spots are cut open, many light yellow, small particles of foam cells, like rice porridge, are seen, and are therefore called “the aorta congee hardened”。
According to a study by the chinese journal of cardiovascular diseases, china is one of the world's most heavily burdened countries with cardiovascular diseases, which account for more than 40 per cent of all deaths in china. Among the different types of cardiovascular disease, the burden of disease in the sclerosis of the aneurystic porridge, mainly among coronary and ischaemic pawns, is growing rapidly in our population, accounting for more than 60 per cent of cardiovascular deaths。
Studies have shown that the inflammation process involves all stages of the life cycle of the avial porridge sclerosis and can be seen as a clear target for mitigating the disease. On 6 march 2023, a study published by the lancet showed that, among patients treated with histinic drugs, vascular inflammation might be more powerful than high cholesterol to predict future cardiovascular events. The article recommends the joint use of active lipid and inflammatory treatments to further reduce the risk of sclerosis of the artery samples. Since the discovery of the self-inflammation mechanism, scientists have been trying to find relevant drugs。
The approval was supported by a multi-country, random double-blind, placebo comparison clinical trial, which was conducted among 5522 chronic coronary patients, all of whom received guidance for medical care (including the use of high doses of histin-type drugs). The test results showed that, compared to the placebo group, the total risk of re-establishment of coronary artery, driven by cardiovascular death, spontaneous myocardial infarction, ischaemic stroke or ischaemic haemorrhage, was 31 per cent when it was treated as an additional drug (one dose per day, 0. 5 mg per day) for high doses of histinoid and other heart disease prophylaxis。
In terms of safety, patients who are unable to withstand the autumn pixieline suffer mainly from gastrointestinal disorders (43%). Upon entering the random testing phase, the patient's long-term tolerance for low-dose aqueous pixieline is better, with a permanent stoppage rate of 10. 5%, the same as for the placebo group. The study was published in new england medical journal (nejm) on 5 november 2020。
Figure a shows the cumulative incidence of cardiovascular death, myocardial infarction, coronary artery re-entry, which is a major complex endpoint driven by anesthesia, and figure b shows the cumulative incidence of a critical sub-complex endpoint in a cardiovascular death, myocardial infarction or ischaemic brain. Source: new england medical journal
The role of the autumn phenomenon in cardiovascular diseases was confirmed in more than one study. In 2013, a test called lodoco found for the first time that 0. 5 mg of aqueous pixieline was administered daily, and that the risk of cardiovascular events was only one third (5. 3% vs 16%) of the control group. However, the test included only more than 500 patients and the sample was small, and the conclusion remains to be confirmed by follow-up studies。
In 2019, a study published in the new england journal of medicine also confirmed the role of aqueous porridge in sclerosis. The researchers recruited 4745 acute myocardial infarction patients. After 22. 6 months of follow-up visits, the risk of re-establishing coronary artery through cardiovascular disease, retrieving cardiac cardiac arrest, heart infarction, mid-to-minus or emergency hospitalization for cardiac pain was found at low doses (5. 5% vs 7. 1%)。
Low-dose autumn alkaline side effects are less risky
Chen hai ice indicates that, in terms of therapeutic efficacy, several past experiments have proven their effectiveness and safety. After several experiments that demonstrated the effectiveness of the autumn spectrum for cardiovascular diseases, it interacted with the cardiologist, who had been proactive in clinically targeting some patients with autumn phenomenon. “some patients have not been particularly stable after having had their hearts filled up and have stabilized after having joined the drug.”
"the value of autumn water fairy is also very high." chen hai ice states that “autumn cuisine, 20 tablets, 1 milligram at a price of 11 yuan/box for cardiovascular disease prevention, can be used for 40 days, assuming 10 boxes a year, only 110 dollars.”
According to chen, most patients and doctors are concerned about the side effects of drugs. In the past, the treatment was limited to the perception of disease, clinically using a large dose for acute pain, one in one hour (1 mg) and six in a row, which could easily result in an intoxication dose leading to diarrhoea, so that the population might consider the autumn phenomenon to be toxic. However, in recent decades, evidence-based clinical evidence has shown that treatment can be achieved without such a large dose, with a maximum of 1. 5 milligrams currently being used for a clinical day。
Lodoco, which was approved by the fda this time, was used in 0. 5 mg/day at a small dose. “the combination of (autumn cactus) and titanoid drugs is safe, even less so than the liver function damage caused by the other. If there is a serious adverse digestive tract reaction after use, such as diarrhoea, it is not appropriate to use it, but most patients are resistant and the incidence of liver damage is extremely low, which can be avoided through review and monitoring.” chen hai ice。
"to accept with an open mind." according to chen, “if you have concerns about this drug, it can be used first and foremost in patients suffering from both arrhythmia and cardiovascular diseases, and it is certain that the patient's prognostic and endurance will benefit from a low dose of cholesterol, based on the previous treatment of low-density protein gholesterics and anti-blood panels”
According to chen sea ice, the international guidance will soon be updated with the inclusion of autumn phenomenon, which can then be applied to clinically。
References:
1. Prevention of cardiovascular disorders to scorrupt porridge, jana, liu jing, chinese journal of cardiovascular diseases, 2022,50 (3): 309-313.
2. Cardivasc res. 2021 nov 22; 117 (13): 2525-2536. Doi: 10. 1093/cvr/cvab303. Doi:10. 1016/j. Annonc2022. 08. 001.
3. Https://www. Thelancet. Com/journals/lancet/article/piis0140-6736(23)00215-5/fulltext
4. Https://pubmed. Ncbi. Nlm. Nih. Gov/31733140
5. Https://us. Agepharpharma. Com/blog/2023/06/20/us-fda-approves-first-anti-info-drag-for-cardiovascular-disease/
